Based on few patients, quinine sulfate reduces the number of night cramps, but not the severity or duration. Patients taking Quinine saw the number of nights cramps decreased. The benefit of quinine seems to be cumulative, and therefore should be taken regularly. Night cramps are painful muscle cramps that occur when the patient is at rest. They are very common in the elderly (over 70%). Quinine, (C 20 H 24 N 2 O 2) is a natural alkaloid, white, crystalline, antipyretic properties, anti-malarial and analgesic. It has a bitter taste. Quinine was first extracted from the bark of cinchona, a tree native to South America. Was isolated and named in 1820 by French researchers Pierre Joseph Pelletier and Joseph Caventou. Its name derives from the Quechua (Native American language) describing the bark of the cinchona tree: quina-quina, meaning bark bark or holly bark. The large scale use of quinine as a prophylactic has its origin in 1850, although its use in Europe dates basck to the seventeenth century. Cinchona bark which contains quinine, was known for its healing properties by Native Americans, but did not joined the European cultural heritage until its antimalarial properties were discovered. Chinchona Bark is still the only practical source of quinine. However, in times of war, efforts were intensified to achieve its total synthesis. The American Chemist R.B. Woodward and W.E. Doergin got it synthesized in 1944.Since then, there have been other total syntheses more effective, but none of them can compete economically with the techniques of isolation and purification of the alkaloid from natural sources