Trust Medichem

Trust Medichem

Tennessee, United States

Apoptosis Activator 2


Apoptosis Activator 2

DESCRIPTION
Synonyms
  • AAII
  • N-(3,4-dichlorobenzyl) Isatin

Apoptosis activator 2 promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome, thus increasing procaspase-9 processing and subsequent caspase-3 activation.1 This compound has been shown to induce apoptosis in leukemia cells (IC50 = 4-9 μM) with weak or no effect on normal cell lines or those lacking Apaf-1, caspase-9, or caspase-3 activity (IC50s > 40 μM).1

 

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TECHNICAL INFORMATION
Formal Name
1-[(3,4-dichlorophenyl)methyl]-1H-indole-2,3-dione
CAS Number
79183-19-0
Synonyms
  • AAII
  • N-(3,4-dichlorobenzyl) Isatin
Molecular Formula
C15H9Cl2NO2
Formula Weight
306.1
Purity
≥95%
Formulation
A crystalline solid
λmax
245, 296 nm
SMILES
O=C1C(C2=CC=CC=C2N1CC3=CC=C(Cl)C(Cl)=C3)=O
InChI Code
InChI=1S/C15H9Cl2NO2/c16-11-6-5-9(7-12(11)17)8-18-13-4-2-1-3-10(13)14(19)15(18)20/h1-7H,8H2
InChI Key
KGRJPLRFGLMQMV-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

 

SHIPPING & STORAGE
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years




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Contact Details

Mr. Francis M.H.

2417, West End Avenue, Nashville, Tennessee, - 37203, United States

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