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treatment of patients with t-cell acute lymphoblastic leukaemia and t-cell lymphoblastic lymphoma whose disease has not responded to or has relapsed following treatment with at least two chemotherapy regimens.

dosage: for adults the recommended dose is 1, 500mg/m2 administered intravenously over two hours on days 1, 3 and 5 and repeated every 21 days. The recommended dose for children is 650mg/m2 administered intravenously over one hour daily for five consecutive days, repeated every 21 days. In clinical studies doses of 650mg/m2 and 1, 500mg/m2 have both been used for patients aged 16 to 21 years, with similar efficacy and safety for both regimens.

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brand name : keytrudacomposition : pembrolizumabmanufactured by :merck msd, inc.strength :50mgform :injectionpacking :pack of 1 vial

keytruda (pembrolizumab) is a cancer medicinethat interferes with the growth and spread of cancer cells in the body.

keytruda is used to treat:

• advanced skin cancer (melanoma) that has spread to other parts of the body or cannot be surgically removed;
• a certain type of non- smell ling cancerif your tumor has a specific genetic marker for which your doctor will test;
• head and neck cancer that has spread to other parts of the body, or has come back after prior treatment;
• classical hodgkin lymphomain adults and children;
• a certain type of bladder and urinary tract cancer that has spread to other parts of the body or cannot be surgically removed; and
• a type of cancer that laboratory testing proves to be a microsatellite instability-high or a mismatch repair deficiency solid tumor.

keytruda is often given after other cancer medicine has been tried without success.

keytruda was approved by the us food and drug administration (fda) on an accelerated basis to treat lung cancer or head and neck cancer. In clinical studies, tumors responded to this medicine. However, it has not been shown that pembrolizumab can improve symptoms or lengthen survival time.

important information

keytruda can change the way your immune system works, which may cause certain side effects that can lead to serious medical problems.

call your doctor at once if you have: chest pain, cough, shortness of breath, vision changes, tiredness, severe muscle pain or weakness, diarrhea and severe stomach pain, blood in your stools, bruising or bleeding, dark urine, yellowing of the skin or eyes, a hormonal disorder (frequent headaches, feeling light-headed, rapid heartbeats, a deeper voice, increased thirst or urination, feeling cold, weight gain or loss), or a change in the amount or color of your urine.

the side effects of keytruda can cause symptoms in many different parts of your body. Some side effects may need to be treated with other medicine, and your cancer treatments may be delayed.you will need frequent medical tests to help your doctor determine if it is safe for you to keep receiving keytruda.do not miss any follow-up visits to your doctor.

before taking this medicine

to make sure keytruda is safe for you, tell your doctor if you have:

• a lung disease or a breathing disorder;
• liver or kidney disease;
• a thyroid disorder;
• an autoimmune disorder such as lupus, crohns disease, or ulcerative colitis; or
• if you have ever had an organ transplants.

do not use keytruda if you are pregnant.it could harm the unborn baby. Tell your doctor right away if you become pregnant during treatment. Use effective birth control while you are using this medicine and for at least 4 months after your last dose.

it is not known whether pembrolizumab passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using keytruda and for at least 4 months after your last dose.

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