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Leading Manufacturer, Supplier & Retailer of Recombinant Human Tyrosine Kinase, Recombinant Rat Activin A Receptor, Recombinant Mouse, Recombinant Human Acetoacetyl and Recombinant Human Acid Phosphatase 1.

Recombinant Mouse

Recombinant Mouse

Brand Name Creative Biomart

We are offering recombinant mouse. mouse adipocyte-specific adhesion molecule (asam), also known as acam and clmp, is a type I transmembrane protein and a member of the ctx (cortical thymocyte marker in xenopus) family within the immunoglobulin superfamily. The extracellular region of human asam contains two potential n-linked glycosylation sites, and two immunoglobulin domains, one variable (v-type) and one constant (c2-type), separated from each other by a j-segment.

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Recombinant Human Acetoacetyl

Recombinant Human Acetoacetyl

We are offering recombinant human acetoacetyl-coa synthetase.acetoacetyl-coa synthetase, also known as acyl-coa synthetase family member 1, protein sur-5 homolog, aacs, and acsf1, is a member of the atp-dependent amp-binding enzyme family. Aacs is highly expressed in kidney, heart and brain, but low in liver. Aacs is an essential enzyme for the synthesis of fatty acid and cholesterol from ketone bodies. Aacs in adipose tissue plays an important role in utilizing ketone body for the fatty acid-synthesis during adipose tissue development. Aacs was found to be highly expressed in mouse adipose tissue, and gc box and cebps motif were crucial for aacs promoter activity. Moreover, aacs promoter activity was controlled mainly by cebpalpha during adipogenesis. Aacs is a novel cytosolic ketone body (acetoacetate)-specific ligase, the physiological role of which remains to be elucidated.

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Recombinant Human Abhydrolase Domain

Recombinant Human Abhydrolase Domain

We are offering recombinant human abhydrolase domain. abhydrolase domain-containing protein 4, also known as lyso-n-acylphosphatidylethanolamine lipase, alphabeta-hydrolase 4 and abhd4, is a protein which belongs to the peptidase s33 family and abhd4 abhd5 subfamily. The alphabeta hydrolase fold is common to a number of hydrolytic enzymes of widely differing phylogenetic origin and catalytic function. The core of each enzyme is an alphabeta-sheet (rather than a barrel), containing 8 strands connected by helices. The enzymes are believed to have diverged from a common ancestor, preserving the arrangement of the catalytic residues. All have a catalytic triad, the elements of which are borne on loops, which are the best-conserved structural features of the fold. Abhd4 lysophospholipase selective for n-acyl phosphatidylethanolamine (nape). Abhd4 contributes to the biosynthesis of n-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from n-acyl phosphatidylethanolamine (nape) generating glycerophospho-n-acyl ethanolamine (gp-nae), an intermediate for n-acyl ethanolamine biosynthesis. Abhd4 hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated n-acyl chains.

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Recombinant Human Acetyl

Recombinant Human Acetyl

Brand Name Creative Biomart

We are offering recombinant human acetyl. acaa1 is a member of the thiolase family of enzymes and is involved in lipid metabolism. This protein is localized to the peroxisome and catalyzes the conversion of acyl-coa and acetyl-coa to 3-oxoacyl-coa in the fatty acid oxidation pathway. Acaa1 shows high enzymatic activity in liver, kidney, intestine and white adipose tissue in rats. Deficiency of this enzyme leads to pseudo-zellweger syndrome.

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Recombinant Human Acyl

Recombinant Human Acyl

Brand Name Creative Biomart

We are offering recombinant human acyl-acadl-1278h. Acadl belongs to the acyl-coa dehydrogenase family, existing as a homotetramer. It is involved in the catabolism of fatty acids and amino acids and they provide a major source of energy for the heart and skeletal muscle. Defect in the gene encoding acadl leads to non-ketotic hypoglycemia and hypotonia and muscle weakness.

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Recombinant Human Acadm

Recombinant Human Acadm

Brand Name Creative Biomart

We are offering recombinant human acadm-725h, acadm, also known as acyl-coenzyme a dehydrogenase is an enzyme that is important for breaking down (degrading) a certain group of fats called medium-chain fatty acids. It is essential for converting these particular fatty acids to energy, especially during periods without food (fasting). This protein functions in mitochondria, the energy-producing centers within cells. It is found in the mitochondria of several types of tissues, particularly the liver.

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Recombinant Human Acyl Coenzyme A Dehydrogenase

Recombinant Human Acyl Coenzyme A Dehydrogenase

Brand Name Creative Biomart

We are offering recombinant human acyl coenzyme a dehydrogenase-acads-1829h. Acads (acyl-coenzyme a dehydrogenase), also known as scad or acad3, is a tetrameric mitochondrial flavoprotein, which is a member of the acyl-coa dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations of acads have been associated with fatty acid oxidation defects and metabolic diseases such as short-chain acyl-coa dehydrogenase deficiency (scad deficiency).

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Recombinant Human Acadvl

Recombinant Human Acadvl

Brand Name Creative Biomart

We are offering recombinant human acadvl-785h. Acadvl, also known as vlcad, lcacd or acad6, is an inner mitochondrial membrane protein that belongs to the family of acyl-coa dehydrogenases. This protein is involved in lipid metabolism and has catalytic activity toward esters of long chain and very long chain fatty acids such as palmitoyl-coa and stearoyl-coa, and functions in the first step of the fatty acid -oxidation pathway. A deficiency in this gene product reduces myocardial fatty acid beta-oxidation and is associated with cardiomyopathy.

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Recombinant Mouse Acetylcholinesterase

Recombinant Mouse Acetylcholinesterase

Brand Name Creative Biomart

We are offering recombinant mouse acetylcholinesterase. mouse acetylcholinesterase, also known as ache, is an enzyme that degrades (through its hydrolytic activity) the neurotransmitter acetylcholine, producing choline and an acetate group. It is mainly found at neuromuscular junctions and cholinergic synapses in the central nervous system, where its activity serves to terminate synaptic transmission. Ache is also found on the red blood cell membranes, where it constitutes the yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms, which possess similar catalytic properties, but differ in their oligomeric assembly and mode of attachment to the cell surface. Ache interacts with prima1. The interaction with prima1 is required to anchor it to the basal lamina of cells and organize into tetramers.

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Recombinant Human Tyrosine Kinase

Recombinant Human Tyrosine Kinase

Brand Name Creative Biomart

We are offering recombinant human tyrosine kinase. the proteins cdc42 is a member of the rho family of small gtpases (g proteins), which control signal-transduction pathways that lead to rearrangements of the cell cytoskeleton, cell differentiation and cell proliferation. A non-receptor tyrosine kinase 2 (tnk2), also known as activated cdc42 kinase 1 (ack1), has been found to bind specifically to the gtp-bound form of cdc42 and serves as a downstream effector of cdc42. Ack1 structrurally consists of (from n-to c-terminus) a kinase catalytic domain, a sh3 domain, and a cdc42-binding crib domain. Ack1 also acts as a mediator of egf signals to rho family gtp-binding proteins through phosphorylation and activation of gefs such as dbl in association with an adaptor protein grb2.

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Recombinant Human Acyl

Recombinant Human Acyl

Brand Name Creative Biomart

We are offering recombinant human acyl. Acyl-coenzyme a thioesterase 13, also known acot13, belongs to the thioesterase subfamily of esterase family. Highly expressed in kidney with moderate expression in brain, liver and intestines, acot13 contains a hotdog-fold and is thought to co-localize with microtubules, possibly playing a role in cellular proliferation events. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus.

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Recombinant Human Acid Phosphatase 1

Recombinant Human Acid Phosphatase 1

Brand Name Creative Biomart

We are offering recombinant human acid phosphatase 1. acid phosphatase 1 ( acp1 ), also named cytosolic low molecular weight phosphotyrosine phosphatase ( lmw-ptp ), is a highly polymorphic phosphatase that is especially abundant in the central nervous system and is known to be involved in several signal transduction pathways. The enzymes belonging to the low-molecular-weight protein tyrosine phosphatase ( lmw-ptp ) family are involved in the regulation of important physiological functions, including stress resistance and synthesis of the polysaccharide capsule. Acp1 functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. Acp1 lmw-ptp is responsible for fcgammariia dephosphorylation, and is implicated in the down-regulation of cell activation mediated by this itam-bearing immunoreceptor. Acp1 is an enzyme that is involved in the early events of platelet-derived growth factor (pdgf) receptor signal transduction. In particular lmw-ptp is involved in pathways that regulate the transcription of the immediately early genes myc and fos in response to growth factor stimulation.

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Recombinant Human Acid Phosphatase

Recombinant Human Acid Phosphatase

Brand Name Creative Biomart

We are offering recombinant human acid phosphatase-like 2. Acid phosphatase-like protein 2, also known as acpl2, is a secreted protein which belongs to the histidine acid phosphatase family. A large-scale effort, termed the secreted protein discovery initiative (spdi), was undertaken to identify novel secreted and transmembrane proteins. In the first of several approaches, a biological signal sequence trap in yeast cells was utilized to identify cdna clones encoding putative secreted proteins. A second strategy utilized various algorithms that recognize features such as the hydrophobic properties of signal sequences to identify putative proteins encoded by expressed sequence tags (ests) from human cdna libraries. A third approach surveyed ests for protein sequence similarity to a set of known receptors and their ligands with the blast algorithm. Finally, both signal-sequence prediction algorithms and blast were used to identify single exons of potential genes from within human genomic

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Recombinant Human Acid Phosphatase

Recombinant Human Acid Phosphatase

Brand Name Creative Biomart

We are offering recombinant human acid phosphatase. prostatic acid phosphatase, also known as acpp, is a secreted and a single-pass type I membrane protein which belongs to the histidine acid phosphatase family. Acpp psap is an enzyme produced by the prostate. It may be found in increased amounts in men who have prostate cancer or other diseases. The highest levels of acpp psap are found in metastasized prostate cancer. Diseases of the bone, such as paget"s disease or hyperparathyroidism, diseases of blood cells, such as sickle-cell disease or multiple myeloma or lysosomal storage diseases, such as gaucher"s disease, will show moderately increased levels. Acpp psap was used to monitor and assess progression of prostate cancer until the introduction of prostate specific antigen (psa), which has now largely displaced it. Acpp psap has a role in prognosticating intermediate and high-risk prostate cancer, it has led to renewed interest in this marker. Its physiological function may be associated with the liquefaction process of semen. Acpp psap may play an important role in the transmission of hiv. Acpp psap forms fibers made of amyloid. There fibers capture hiv virions promoting their attachment to target cells. The association of acpp psap with hiv may increase the ability of the virus to infect human cells "by several orders of magnitude." acpp psap may be a future target of efforts to combat the spread of hiv infection.

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Recombinant Human Acrosomal Vesicle Protein 1

Recombinant Human Acrosomal Vesicle Protein 1

Brand Name Creative Biomart

We are offering recombinant human acrosomal vesicle protein 1. acrv1 is a testis-specific, differentiation antigen, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. Acrv1 is a testis-specific acrosomal protein that has been detected in several species including humans. It may be involved in sperm-zona binding or penetration, and it is a potential contraceptive vaccine immunogen for humans. Acrv1 may be involved in sperm-zona binding or penetration.

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Recombinant Human Actin

Recombinant Human Actin

Brand Name Creative Biomart

We are offering recombinant human actin. Beta actin is one of six different actin isoforms that have been identified. Actb is one of the two nonmuscle cytoskeletal actins. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.

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Recombinant Human Actin

Recombinant Human Actin

Brand Name Creative Biomart

We are offering recombinant human actin. beta actin is one of six different actin isoforms that have been identified. Actb is one of the two nonmuscle cytoskeletal actins. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.

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Recombinant Mouse Activin A Receptor

Recombinant Mouse Activin A Receptor

Brand Name Creative Biomart

We are offering recombinant mouse activin a receptor, type 1, his-fc. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (tgfbeta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and ib) and two type ii (ii and iib) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serinethreonine specificity. Type I receptors are essential for signaling, while type ii receptors are required for binding ligands and for expression and phosphorylation of type I receptors. Acvr1, also termed as alk2, actri, skr1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with actrii or iib. In addition, alk2 is also identified as a bmp type I receptor which has been demonstrated to form complex with either the bmp-27-bound bmpr-ii or acvr2aacvr2b. Acvr1 may be involved in left-right pattern formation during embryogenesis, and mutations in acvr1 gene are associated with fibrodysplasia ossificans progressive.

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Recombinant Human Activin A Receptor

Recombinant Human Activin A Receptor

Brand Name Creative Biomart

We are offering recombinant human activin a receptor. activin rib, also known as alk4, is a glycosylated type I receptor in the superfamily of tgf- serinethreonine kinase receptors. Activin rib associates with activin riib to form a receptor complex for activin and inhibin molecules. These ligands bind to activin riib which then associates with and phosphorylates the cytoplasmic domain of activin rib to initiate signal transduction.within the ecd, human activin rib shares 93% and 95% aa sequence identity with mouse and rat activin rib, respectively. It shares 25% - 35% aa sequence identity with other human type I receptors activin ria, activin ric, bmpr-ia, bmpr-ib, and tgf- r1. Alternately spliced isoforms of activin rib have deletions in the cytoplasmic domain and function as dominant negative inhibitors of activin signaling. Activin receptor signaling is modulated by the direct interaction of activin rib with cripto or inhibin binding protein. Activin rib is excluded from the signaling complex if activin riib first binds inhibin and betaglycan. Activin rib functions in a wide variety of growth and differentiation processes, including embryonic cell fate and axis determination, cell proliferation and apoptosis, and tumorigenesis.

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Recombinant Human Activin A

Recombinant Human Activin A

Brand Name Creative Biomart

We are offering recombinant human activin a receptor, type ib, fc-tagged. acvrib is a single-pass type I membrane protein which belongs to the protein kinase superfamily and tgfb receptor subfamily. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta superfamily of structurally related signaling proteins.

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Recombinant Human Activin A Receptor

Recombinant Human Activin A Receptor

Brand Name Creative Biomart

We are offering Recombinant Human Activin a Receptor. Activin receptor type-IB, also known as Serinethreonine-protein kinase receptor R2, Activin receptor-like kinase 4, ALK-4, and ACVRIB, is a single-pass type I membrane protein which belongs to the protein kinase superfamily and TGFB receptor subfamily. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serinethreonine specificity. ALK-4 is expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.

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Recombinant Human Activin A Receptor

Recombinant Human Activin A Receptor

Brand Name Creative Biomart

We are offering Recombinant Human Activin a Receptor. Activin isoforms which belong to the transforming growth factor-beta (TGF-) superfamily exert their biological actions by binding to heteromeric receptor complexes consisting of at least a type I and a type II receptor of serinethreonine kinase These activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with serinethreonine kinase.

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Recombinant Mouse Activin Receptor IIA

Recombinant Mouse Activin Receptor IIA

Brand Name Creative Biomart

We are offering recombinant mouse activin receptor iia, his-taggedactivin isoforms which belong to the transforming growth factor-beta (tgf-) superfamily exert their biological actions by binding to heteromeric receptor complexes consisting of at least a type I and a type ii receptor of serinethreonine kinase these activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with serinethreonine kinase. Type I receptors are essential for signal transduction and type ii receptors are required for ligand binding and the expression of type I receptors. On ligand binding, type I and ii receptors form a stable complex, resulting in phosphorylation of type I receptors by type ii receptors with constitutive kinase activity, and subsequently initiates the activation of downstream molecules. Several type ii activin receptors have been identified and bind to different activins with different affinities. Besides, this typeactivin receptor also bind inhibin, bmp-2 and bmp-7 with lower affinities.

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Recombinant Mouse Activin Receptor Iia

Recombinant Mouse Activin Receptor Iia

Brand Name Creative Biomart

We are offering recombinant mouse activin receptor iiaactivin isoforms which belong to the transforming growth factor-beta (tgf-) superfamily exert their biological actions by binding to heteromeric receptor complexes consisting of at least a type I and a type ii receptor of serinethreonine kinase these activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with serinethreonine kinase. Type I receptors are essential for signal transduction and type ii receptors are required for ligand binding and the expression of type I receptors. On ligand binding, type I and ii receptors form a stable complex, resulting in phosphorylation of type I receptors by type ii receptors with constitutive kinase activity, and subsequently initiates the activation of downstream molecules. Several type ii activin receptors have been identified and bind to different activins with different affinities. Besides, this typeactivin receptor also bind inhibin, bmp-2 and bmp-7 with lower affinities.

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Recombinant Mouse Activin Receptor IIB

Recombinant Mouse Activin Receptor IIB

Brand Name Creative Biomart

We are offering recombinant mouse activin receptor iib, fc chimera-acvr2b-198m. Activin a receptor, type iib, also known as acvr2b, is an activin type 2 receptor. Activins are dimeric growth and differentiation factors belonging to the tgf-beta superfamily. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (i and ib) and two type ii (ii and iib) receptors. Mouse acvr2b is a transmembrane proteins consisting of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane segment, a cytoplasmic domain with predicted serinethreonine specificity, and as well as a c-terminal pdz binding motif. Mouse acvr2b shares 99% aa sequence identity with human and rat within ecd.

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Recombinant Mouse Activin Receptor Iib

Recombinant Mouse Activin Receptor Iib

Brand Name Creative Biomart

We are offering recombinant mouse activin receptor iib, his-tagged-acvr2b-424m. Activin a receptor, type iib, also known as acvr2b, is an activin type 2 receptor. Activins are dimeric growth and differentiation factors belonging to the tgf-beta superfamily. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (i and ib) and two type ii (ii and iib) receptors. Type I receptors are essential for signaling, and type ii receptors are required for binding ligands and for expression of type I receptors. On ligand binding, type I and ii receptors form a stable complex, resulting in phosphorylation of type I receptors by type ii receptors with constitutive kinase activity, and subsequently the initiates activation of downstream molecules. The activin a type iib receptor displays a 3- to 4-fold higher affinity for the ligand than the type ii receptor. Mouse activin receptor iib (acvr2b) is a transmembrane proteins consisting of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane segment, a cytoplasmic domain with predicted serinethreonine specificity, and as well as a c-terminal pdz binding motif . Mouse acvr2b shares 99% aa sequence identity with human and rat within ecd.

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Recombinant Human Activin A Receptor

Recombinant Human Activin A Receptor

Brand Name Creative Biomart

We are offering recombinant human activin a receptor, type iib-acvr2b-1586h. Activin a receptor, type iib, also known as acvr2b, is a human gene.[1] acvr2b is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (tgf-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (i and ib) and two type ii (ii and iib) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serinethreonine specificity. Type I receptors are essential for signaling; and type ii receptors are required for binding ligands and for expression of type I receptors. Type I and ii receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type ii receptors. Type ii receptors are considered to be constitutively active kinases. This gene encodes activin a type iib receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin a type ii receptor. Activin type ii receptors are highly conserved. Human, mouse and rat type ii activin receptors share greater than 98% amino acid sequence homology. Recombinant soluble activin type ii receptors bind activin with high affinity, and are potent activin antagonists.

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Recombinant Human Activin A Receptor

Recombinant Human Activin A Receptor

Brand Name Creative Biomart

We are offering recombinant human activin a receptor, type iib, fc chimera-acvr2b-196h. Activin isoforms are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (tgf-) superfamily of structurally related signaling proteins. Activins exert their biological actions by binding to heteromeric receptor complexes consisting of at least a type I (i and ib) and a type ii (ii and iib) receptor. These activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serinethreonine kinase.

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Recombinant Human Activin A Receptor

Recombinant Human Activin A Receptor

Brand Name Creative Biomart

We are offering Recombinant Human Activin A Receptor, Type IIB, His-tagged-ACVR2B-197H. Activin isoforms are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-) superfamily of structurally related signaling proteins. Activins exert their biological actions by binding to heteromeric receptor complexes consisting of at least a type I (I and IB) and a type II (II and IIB) receptor. These Activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serinethreonine kinase.

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Recombinant Mouse Activin A Receptor

Recombinant Mouse Activin A Receptor

Brand Name Creative Biomart

We are offering recombinant mouse activin a receptor-acvrl1-2333m, type ii-like 1, fc-his. Mouse activin a receptor, type ii-like 1 (acvrl1), also known as alk1, is an endothelial-specific type I receptor of the tgf-beta (transforming growth factor beta ) receptor family which is implicated in angiogenesis and in the pathogenesis of the hereditary hemorrhagic telangiectasia type 2 (hht2) and vascular disease. Heterozygous alk1 mutations cause hereditary hemorrhagic telangiectasia type 2 (hht2) which is a multisystemic vascular disorder. Tgf-beta1 has been considered as the most likely alk1 ligand related to hht. In cultured endothelial cells, alk1 and another tgf-beta type I receptor, alk5, regulate angiogenesis by controlling tgf-beta signal transduction, and alk5 is required for alk1 signaling. Genetic studies in mouse and zebrafish have established the importance of alk1 in formation and remodeling of blood vessels. Expression of alk1 in blood vessels and mutations of the alk1 gene in human suggest that alk1 have an important role during vascular development.

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Recombinant Rat Activin A Receptor

Recombinant Rat Activin A Receptor

Brand Name Creative Biomart

We are offering recombinant rat activin a receptor type ii-like 1, fc-his-acvrl1-245r. Rat activin a receptor, type ii-like 1 (acvrl1), is a type I cell-surface receptor for the tgf-beta superfamily of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type ii and two type I transmembrane serinethreonine kinases. Constitutively active type ii receptors phosphorylate and activate type I receptors on ligand binding, and in turn, type I kinase phosphorylates down stream signal molecules including various smad transcriptional regulators. Rat acvrl1 contains a serine-threonine kinase sub-domains, and a glycine and serine-rich region (called the gs domain) preceding the kinase domain, sharing a high degree of structure similarity with human and mouse alk1.

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Recombinant Human Activin A Receptor

Recombinant Human Activin A Receptor

Brand Name Creative Biomart

We are offering recombinant human activin a receptor type ii-like 1, his-tagged-acvrl1-644h. Alk1 is a type I cell-surface receptor for the tgf-beta superfamily of ligands. The heteromeric receptor complex consists of two types (i and ii) transmembrane serinethreonine kinases, among which, constitutively active type ii receptors phosphorylate and activate type I receptors on ligand binding, and in turn, type I kinase phosphorylates down stream signal molecules including various smad transcriptional regulators. Alk1 shares a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the gs domain) preceding the kinase domain, and a short c-terminal tail with other activin receptor-like kinase proteins. Alk1 has been suggested to be implicated in the blood vessel development and repair. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as rendu-osler-weber syndrome 2.

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Recombinant Mouse Angiotensin I Converting Enzyme

Recombinant Mouse Angiotensin I Converting Enzyme

Brand Name Creative Biomart

We are offering recombinant mouse angiotensin I converting enzyme-ace2-1183m(peptidyl-dipeptidase a)2, fc-tagged, also known as ace-related carboxypeptidase, angiotensin-converting enzyme homolog, metalloprotease mprot15, aceh and ace2, is a single-pass type I membrane protein which belongs to the peptidase m2 family. Aceh ace2 is identified as a zinc metalloprotease structurally consisting of a nterminal signal peptide, a single catalytic domain, a c-terminal membrane anchor, and a short cytoplasmic tail. Aceh ace2 is expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. It is expressed in lung alveolar epithelial cells, enterocytes of the small intestine, leydig cells and sertoli cells (at protein level). It is expressed in heart, kidney, testis, and gastrointestinal system.

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Recombinant Mouse Angiotensin I Converting Enzyme

Recombinant Mouse Angiotensin I Converting Enzyme

Brand Name Creative Biomart

We are offering recombinant mouse angiotensin I converting enzyme-ace2-1184m(peptidyl-dipeptidase a) 2, his-tagged. Mouse angiotensin-converting enzyme 2, also known as ace-related carboxypeptidase, angiotensin-converting enzyme homolog, metalloprotease mprot15, aceh and ace2, is a single-pass type I membrane protein which belongs to the peptidase m2 family. Aceh ace2 is identified as a zinc metalloprotease structurally consisting of a nterminal signal peptide, a single catalytic domain, a c-terminal membrane anchor, and a short cytoplasmic tail. Aceh ace2 is expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. It is expressed in lung alveolar epithelial cells, enterocytes of the small intestine, leydig cells and sertoli cells (at protein level). It is expressed in heart, kidney, testis, and gastrointestinal system.

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Recombinant Rattus Angiotensin I Converting Enzyme

Recombinant Rattus Angiotensin I Converting Enzyme

Brand Name Creative Biomart

We are offering recombinant rattus angiotensin I converting enzyme-1194r (peptidyl-dipeptidase a) 2, his-tagged, also known as ace-related carboxypeptidase, angiotensin-converting enzyme homolog, metalloprotease mprot15, aceh and ace2, is a single-pass type I membrane protein which belongs to the peptidase m2 family. Aceh ace2 is identified as a zinc metalloprotease structurally consisting of a nterminal signal peptide, a single catalytic domain, a c-terminal membraneanchor, and a short cytoplasmic tail. Aceh ace2 is expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. It is expressed in lung alveolar epithelial cells, enterocytes of the small intestine, leydig cells and sertoli cells (at protein level). It is expressed in heart, kidney, testis, and gastrointestinal system.

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Nickel Beads

Nickel Beads

Recombinant proteins tagged with 6-10 poly Histidines can be purified in one step by ion metal affinity chromatography (IMAC). Several metal ions exhibiting affinity to poly-Histidines are commonly used, Nickel and Cobalt being the most popular. Tagging the proteins may be done at the N-ter or the C-ter by cloning a gene in dedicated expression vectors encoding to the poly Histidines stretch, enabling the purification of the recombinant protein resulted.

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Thin Layer Chromatography

Thin Layer Chromatography

Thin layer chromatography is performed on a sheet or plate (about 0.25mm thick) of glass, aluminum foil or plastic which is coated with a thin layer of solid ADSORBENT material.

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Aluminium Oxide Chromatography

Aluminium Oxide Chromatography

Generally aluminium oxide is another stationery phase well-known adsorbent, used in chromatography for less polar compounds. Aluminium oxide powder is a white to off white, fine and grained powder with highly porous from alumina. Its surface is extra polar than that of silica gel and reflecting the amphoteric nature of aluminium, has both basic and acidic features. Aluminium oxide chromatography attributes are determined by its specific (internal) surface area measured by the BET Method, it means pore diameter, and its pore volume, the last mentioned two being in relative to the specific surface area.

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Aromatic Polymer Adsorbent Resin

Aromatic Polymer Adsorbent Resin

Aromatic polymer adsorbent resin is a macroreticular, non-fuctionalised adsorbent resin designed for the juice processing market where local regulations allow for such use. It can also be used for a wide variety of food processing applications to both recover high value materials and to purify and decolourise food and food additive streams.

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Inclusion Body Protein Isolation Maxi Kit

Inclusion Body Protein Isolation Maxi Kit

The Inclusion Body Isolation Maxi Kit is a complete kit that is designed for the purification of recombinant proteins expressed in bacteria as inclusion bodies. Bacteria are widely used for the expression of different recombinant protein, however 70-80% of the proteins expressed in E. coli by recombinant techniques are contained in inclusion bodies (i.e., protein aggregates). This kit is stream-lined for rapid and efficient cell lysis, protein solubilization and on-column protein purification of up to 12 mg of proteins from 100 mL of bacterial culture.

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DVS-Activated Beads

DVS-Activated Beads

Divinyl Sulfone (DVS) Activated Beads are rigid Sepharose beads loaded with high density of reactive groups. The matrix is suitable for binding amino, or hydroxyl groups, Present on biomolecules such as proteins and carbohydrates. The DVS activated beads are stable for extended period of time when stored refrigerated and light-protected. Coupling reactions to biomolecules may be done between pH values of 8-10 pH.

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N-hydroxysuccinimide Ester 15 Resin

N-hydroxysuccinimide Ester 15 Resin

The N-hydroxysuccinimide ester 15 resin is activated immunoaffinity supports that offer rapid, high efficiency coupling for all ligands with a primary amino group, including proteins throughout the entire range of pIs and low molecular weight compounds such as peptides. The resin supports are N-hydroxysuccinimide esters of a derivatized crosslinked agarose gel bead support, and both couple to ligands spontaneously in aqueous or non-aqueous solution.

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Hz Hydrazide Resin

Hz Hydrazide Resin

The Hz hydrazide resin activated support couples immunoglobulin G (IgG) molecules via carbohydrate moieties on the Fc region of antibody molecules. Fc attachment results in a more specific antigen-antibody interaction and 100300% higher antigen binding capacity than other resins. The resin is a unique approach to IgG coupling to an agarose support matrix for affinity purification.This resin achieves a more uniform orientation of coupled antibody than currently available activated supports which couple via primaryamines.

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Polymyxin B Agarose

Polymyxin B Agarose

The polymyxin B is intended for use in low, medium, or high pressure chromatographic applications. The support consists of polymeric macroporous (1, 000 ?) 45m beads with USP Grade polymyxin B covalently attached. The main application of this product is the removal of endotoxin molecules from biological and aqueous solutions by affinity chromatography. For best performance, this product should be used in dust-freeGMP-grade facilities, all buffers and solutions should be prepared with pyrogen-free water, and, after use, the matrix should be sanitized before use again by treatment with 0.1 N NaOH. Contact time with 0.1 N NaOH should be minimized. Chromatography can beperformed at room temperature or at 4C.

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Agarose

Agarose

Agarose Fast Flow gel filtration medium is based on cross-linked agarose matrix, which gives good physical stability and chromatographic qualities. It is a gel filtration medium developed for industrial processing at high flow rates and moderate pressures.

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Alcohol Dehydrogenase Detection Kit

Alcohol Dehydrogenase Detection Kit

Alcohol Dehydrogenase Detection Kit provides a convenient tool for sensitive detection of the Alcohol DH in a variety of samples. In the assay Alcohol DH will utilize isopropanol as a substrate leading to a proportional color development. The activity of ADH can be easily quantified colorimetrically (? = 450 nm). This assay detects ADH activity as low as 0.01 mU in samples.

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Adipogenesis Assay Kit

Adipogenesis Assay Kit

Adipogenesis is the process of differentiation of different cell types into adipocytes, the primary fat storage cell type. The accumulation of adipocytes is the basis for obesity, a significant risk factor in many diseases, including diabetes, atherosclerosis, cancer and cardiovascular disease, etc. Adipocytes accumulate triglycerides, in the form of lipid droplets which can be measured. The Adipogenesis Assay Kit quantifies triglyceride accumulation in cells and tissues. In the assay, triglycerides are efficiently solubilized then hydrolyzed to glycerol which is subsequently oxidized to convert the probe to generate color (max = 570 nm) and fluorescence (ExEm = 535587 nm). The kit can detect triglyceride in as few as a thousand or less differentiated 3T3-L1 cells with triglyceride detection linear range 0.2 to 10 nmol. The high detection sensitivity and the convenient microplate assay format make the kit a convenient tool for studying the effect of adipogenesis inducers or inhibitors, or to screen drugs.

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cAMP ADORA2B CHO-K1 GPCR Assay Kit

CAMP ADORA2B CHO-K1 GPCR Assay Kit

cAMP cells are engineered to overnaturally Gi or Gs coupled, wildtype GPCRs and are designed to detect changes in intracellular cAMP levels in response to agonist stimulation of the receptor. These cells have been modified to prevent long term propagation and expansion using a proprietary compound that has no apparent effect on assay performance.

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CHO-K1 ADORA3 Bioassay Kit

CHO-K1 ADORA3 Bioassay Kit

The ER (Estrogen Receptor) Alpha Competitor Assay Kit, Red, provides a sensitive and efficient method for high-throughput, fluorescence polarization-based screening of potential ER alpha ligands. The kit uses insect cell-expressed, full-length, native (untagged) human estrogen receptor alpha (available separately, Cat. No. A15674) and a novel, high-affinity, fluorescent estrogen ligand (Fluormone EL Red) in a homogenous, mix-and-read assay format.

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Kit-1106

Kit-1106

-Arrestin GPCR cells are engineered to co-the ProLink (PK) tagged GPCR and the Enzyme Acceptor (EA) tagged -Arrestin. Activation of the GPCR-PK induces -Arrestin-EA recruitment, forcing complementation of the two -galactosidase enzyme fragments (EA and PK). The resulting functional enzyme hydrolyzes substrate to generate a chemiluminescent signal. These cells have been modified to prevent long term propagation and expansion using a proprietary compound that has no apparent effect on assay performance.

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