Hbx is a hepatitis b viral protein.the protein is 154 amino acids long and interferes with transcription, signal transduction, cell cycle progress, protein degradation, apoptosis and chromosomal stability in the host. It forms a heterodimeric complex formation with its cellular target protein (hbx interacting protein: hbxip) which triggering deregulation of centrosome dynamics and mitotic spindle formation. It interacts with ddb1 (damaged dna binding protein 1) redirecting the ubiquitin ligase activity of the cul4-ddb1 e3 complexes, which are intimately involved in the intracellular regulation of dna replication and repair, transcription and signal transduction.although protein x is normally absent in the avihepadnavirus, a vestigial version has been identified in the duck hepatitis virus genome.
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