Caslink Biotech Trading LLC

United States

What is Opdivo (nivolumab) for?
Opdivo (nivolumab) is indicated for the treatment of patients with:
    metastatic melanoma as a single agent or in combination with ipilimumab
    metastatic non-small cell lung cancer (NSCLC) whose cancer progressed on or after chemotherapy
    advanced renal cell carcinoma who have received prior anti-angiogenic therapy
    classical Hodgkin lymphoma that has relapsed or progressed after other treatment.
    recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) with disease progression on or within 6 months of receiving platinum-based chemotherapy
    locally advanced unresectable or metastatic urothelial carcinoma following progression on a platinum-containing therapy[10]
    microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) metastatic colorectal cancer (mCRC) that has progressed following treatment with a fluoropyrimidine, oxaliplatin, and irinotecan
    hepatocellular carcinoma in patients who have been previously treated with sorafenib    for the adjuvant treatment of completely resected esophageal or gastroesophageal junction (GEJ) cancer with residual pathologic disease in patients who have received neoadjuvant chemoradiotherapy (CRT).

How does Opdivo (nivolumab) work?
Opdivo (nivolumab) has been designed to attach to a receptor called PD-1, found on certain cells of the immune system called T cells. Cancer cells can produce proteins (PD-L1 and PD-L2) that attach to this receptor, switching off the T cells. By attaching to the receptor, nivolumab prevents cancer cells from switching off T cells, thereby increasing the ability of the immune system to kill cancer cells.

Polivy (polatuzumab vedotin-piiq) is a medication indicated in combination with bendamustine and a rituximab product for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma, not otherwise specified, after at least two prior therapies. Diffuse large B-cell lymphoma is a type of non-Hodgkin lymphoma.

 Uses
Ipilimumab is used to treat various cancers. Ipilimumab belongs to a class of drugs known as monoclonal antibodies. It works by slowing or stopping the growth of cancer cells. However, it can have serious side effects in other parts of your body (see also Side Effects section).How to use Yervoy Vial
Read the Medication Guide and Patient Wallet Card provided by your pharmacist before you start using ipilimumab and before each treatment with this medication. If you have any questions, ask your doctor or pharmacist. Carry the Patient Wallet Card with you at all times. Show the card to all of your health care providers to let them know that you are being treated with ipilimumab.
This medication is given by injection into a vein as directed by your doctor, usually by slow injection over 30 or 90 minutes. The injection is given by a health care professional. The dosage and treatment schedule are based on your medical condition, weight, and response to treatment.
To decrease the risk of side effects, your doctor may prescribe other medications to take along with this medication. Carefully follow your doctor's directions for all your medications.
Infusion reactions may occur while you are receiving this drug. Tell your doctor right away if you have symptoms such as shortness of breath, feeling faint, dizziness, or fever.