Anti Cancer Medicine #12061085

Herceptin (Trastuzumab) 600mg
UsesTrastuzumab is used alone or with other medications to treat certain types of breast cancer. It is also used along with other medications to treat certain types of stomach cancer. The types of cancers trastuzumab is used to treat are tumors that produce more than the normal amount of a certain substance called HER2 protein.This medication is called a monoclonal antibody. It works by attaching to the HER2 cancer cells and blocking them from dividing and growing. It may also destroy the cancer cells or signal the body (immune system) to destroy the cancer cells.
Herceptin is indicated for the treatment of adult patients with HER2 positive metastatic breast cancer (MBC):
– as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. Prior chemotherapy must have included at least an anthracycline and a taxane unless patients are unsuitable for these treatments. Hormone receptor positive patients must also have failed hormonal therapy, unless patients are unsuitable for these treatments.
– in combination with paclitaxel for the treatment of those patients who have not received chemotherapy for their metastatic disease and for whom an anthracycline is not suitable.
– in combination with docetaxel for the treatment of those patients who have not received chemotherapy for their metastatic disease.
– in combination with an aromatase inhibitor for the treatment of postmenopausal patients with hormone-receptor positive MBC, not previously treated with trastuzumab.
Early breast cancer
Herceptin is indicated for the treatment of adult patients with HER2 positive early breast cancer (EBC).
– following surgery, chemotherapy (neoadjuvant or adjuvant) and radiotherapy (if applicable) (see section 5.1).
– following adjuvant chemotherapy with doxorubicin and cyclophosphamide, in combination with paclitaxel or docetaxel.
– in combination with adjuvant chemotherapy consisting of docetaxel and carboplatin.
– in combination with neoadjuvant chemotherapy followed by adjuvant Herceptin therapy, for locally advanced (including inflammatory) disease or tumours > 2 cm in diameter (see sections 4.4 and 5.1).
Herceptin should only be used in patients with metastatic or early breast cancer whose tumours have either HER2 overexpression or HER2 gene amplification as determined by an accurate and validated assay (see sections 4.4 and 5.1).
4.2 Posology and method of administrationHER2 testing is mandatory prior to initiation of therapy (see sections 4.4 and 5.1). Herceptin treatment should only be initiated by a physician experienced in the administration of cytotoxic chemotherapy (see section 4.4), and should be administered by a healthcare professional only.
It is important to check the product labels to ensure that the correct formulation (intravenous or subcutaneous fixed dose) is being administered to the patient, as prescribed. Herceptin subcutaneous formulation is not intended for intravenous administration and should be administered via a subcutaneous injection only.
Switching treatment between Herceptin intravenous and Herceptin subcutaneous formulations and vice versa, using the three-weekly (q3w) dosing regimen, was investigated in study MO22982 (see section 4.8).
In order to prevent medication errors it is important to check the vial labels to ensure that the drug being prepared and administered is Herceptin (trastuzumab) and not Kadcyla (trastuzumab emtansine).

Avastin 400 mg Injection is an anti-cancer medicine. Avastin 400 mg Injection is used with other medicines to treat certain types of cancers, including Colon Cancer (A cancer of the colon or rectum), Non-Small Cell lung cancer (a group of lung cancers), Glioblastoma (Brain cancer), Kidney cancer, Ovarian cancer, etc. Avastin 400 mg Injection is a monoclonal antibody that targets a protein called vascular endothelial growth factor (VEGF). VEGF plays a role in the growth of new blood vessels, and inhibiting its activity can help to slow the growth and spread of cancer cells.
Avastin 400 mg Injection may result in some common adverse effects, such as dizziness, heartburn, loss of appetite, change in taste perception, diarrhoea, weight loss, skin or mouth sores, voice changes, and alterations in tear production. However, Avastin 400 mg Injection may also lead to more severe side effects, such as an increased risk of bleeding and the development of new blood vessel growths in various organs and skin, as well as high blood pressure, kidney problems, and protein in the urine. In case of persistent or troublesome side effects, it is important to inform your physician immediately for further guidance.
Avastin 400 mg Injection should be given intravenously. Your doctor will determine the appropriate dosage and frequency of administration based on the severity of your condition, which may be subject to change. It is important to follow your doctor's instructions for taking Avastin 400 mg Injection, as improper or excessive intake may lead to severe adverse effects. Although it may take several weeks or months to observe the benefits of the medication, it is essential not to discontinue treatment unless your doctor tells you to.
Avastin 400 mg Injection should not be used if you have a known allergy or hypersensitivity to Avastin 400 mg Injection or any of its components. You should inform your doctor if you are using any prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products, Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may interact with Avastin 400 mg Injection, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using.

Kryxana 200mg Tablet is an anti-cancer medicine used in the treatment of metastatic breast cancer. It helps to slow down the growth of cancer cells and eventually kills them. This way it treats the symptoms of breast cancer such as breast lumps, bloody discharge from nipples, or changes in the shape of the breast.

Kryxana 200mg Tablet may be taken with or without food and usually taken in combination with another medicine. The duration of treatment varies on the basis of your need and response to treatment. Take it in the exact dose and duration prescribed by your doctor. You may be asked for regular blood tests while taking this medication.

Common side effects of this medicine include decreased white blood cell count, nausea, fatigue, diarrhea, hair loss, vomiting, constipation, headache, and back pain. Neutropenia is a well-recognized adverse effect, in which the number of your white blood cells get reduced and your immune system gets weakened. As a result, you may be at greater risk of getting an infection. However, this side effect disappears rapidly once you stop taking the medicine.

Before using this medicine, let your doctor know if you have any preexisting medical conditions. Let your doctor also know about all the medications you are taking. Additionally, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Uses of Kryxana Tablet
    Metastatic breast cancer
Benefits of Kryxana TabletIn Metastatic breast cancerKryxana 200mg Tablet helps to treat breast cancer and it may be used alone or in combination with other medicines or treatment modalities like chemotherapy. This medicine is used when other medicines have not shown significant improvement and the cancer has spread to other parts as well. It relieves the symptoms of breast cancer such as breast lumps, bloody discharge from nipples or changes in the shape or texture of the breast. Kryxana 200mg Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. Discuss with your doctor if any of the side effects bother you.


Side effects of Kryxana TabletMost side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about themCommon side effects of Kryxana
    Decreased white blood cell count    Nausea    Fatigue    Diarrhea    Hair loss    Vomiting    Constipation    Headache    Back pain


How to use Kryxana TabletTake this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Kryxana 200mg Tablet may be taken with or without food, but it is better to take it at a fixed time.


How Kryxana Tablet worksKryxana 200mg Tablet is an anti-cancer medication. It works by blocking proteins (kinases) which are important for the growth and division of cells. This slows the growth of cancer cells and eventually kills them.

Buy Rapamune Tablets in India
Rapamune Tablet is an immune-suppressant, which in combination with different drugs is utilized amid kidney transplant to counteract rejection. It is likewise used to coat coronary stents and treat lymphangioleiomyomatosis. This drug is generally taken once every day, except talk to your specialist in regards to the appropriate dose. Rapamune Tablet contains Sirolimus as an active ingredient.
Rapamune debilitates your body's immune system, to help keep it from rejecting a transplanted organ, for example, a kidney. Organ rejection happens when the immune system regards the new organ as an invader and attacks it.What are the side-effects of RAPAMUNE Tablet?
An expanded danger of contamination
Mouth ulcer
Diminished platelets (red cells, white cells, and platelets)
Nausea
Stomach upset
Vomiting
Protein in pee
Important Information
You ought not to utilize Rapamune if you have ever had a lung transplant or liver transplant.
Rapamune may make your body overproduce white platelets. This can prompt cancer, extreme brain contamination causing inability or death, or viral contamination causing kidney transplant failure.
Talk to your specialist promptly if you have: fever, influenza side effects, burning when you urinate, another skin injury, any change in your psychological state, decreased vision, a shortcoming on one side of your body, issues with walking or speech, or torment around your transplant.
You might be regularly checked for renal function amid concomitant administration of sirolimus and ciclosporin.
How to use RAPAMUNE Tablet?
Take the Rapamune tablet by mouth as instructed by your specialist, generally once every day. Take this prescription whole. Try not to split, chew, or break the tablets. If you have sickness or stomach upset, you may take this cancer medicine with food. However, it is vital to choose one way (with a meal or without a meal) and take this prescription at a similar time with each dose. Talk to your specialist or drug specialist for more subtleties.How does RAPAMUNE Tablet work?
Rapamune 1 mg Tablet is an immunosuppressant. It works by suppressing our body's insusceptible reaction following the transplant of an organ (e.g. liver, kidney, heart). This encourages your body to accept the new organ as though it were your own.
Precautions
You ought not to utilize Rapamune on the off chance that you are adversely affected by Rapamune, or if you have ever had a lung transplant or liver transplant.
Tell your specialist if you have ever had:
elevated cholesterol or triglycerides;
cytomegalovirus (CMV);
liver infection; or
A family history of skin cancer (melanoma).
Try not to utilize Rapamune in the event that you are pregnant. Utilize powerful conception prevention to anticipate pregnancy while you are taking this drug, and for somewhere around 12 weeks after your last dose.
You ought not to breastfeed while utilizing this drug.
Rapamune ought not to be given to a child more youngsters than 13 years of age.
When not to use Rapamune Tablet?
Allergy to Rapamune Tablet is a contraindication. Apart from this, Rapamune Tablet ought not to be utilized if you have the following conditions:
Concomitant live immunizations
Adverse allergic reaction to it or macrolide antibiotics

Pembrolizumab is a humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2. Pembrolizumab is an IgG4 kappa immunoglobulin with an approximate molecular weight of 149 kDa. Pembrolizumab is produced in recombinant Chinese hamster ovary (CHO) cells.
KEYTRUDA for injection is a sterile, preservative-free, white to off-white lyophilized powder in single-dose vials. Each vial is reconstituted and diluted for intravenous infusion. Each 2 mL of reconstituted solution contains 50 mg of pembrolizumab and is formulated in L-histidine (3.1 mg), polysorbate 80 (0.4 mg), and sucrose (140 mg). May contain hydrochloric acid/sodium hydroxide to adjust pH to 5.5.
KEYTRUDA injection is a sterile, preservative-free, clear to slightly opalescent, colorless to slightly yellow solution that requires dilution for intravenous infusion. Each vial contains 100 mg of pembrolizumab in 4 mL of solution. Each 1 mL of solution contains 25 mg of pembrolizumab and is formulated in: L-histidine (1.55 mg), polysorbate 80 (0.2 mg), sucrose (70 mg), and Water for Injection, USP.INDICATIONSMelanoma
KEYTRUDA® (pembrolizumab) is indicated for the treatment of patients with unresectable or metastatic melanoma.
KEYTRUDA is indicated for the adjuvant treatment of patients with melanoma with involvement of lymph node(s) following complete resection.Non-Small Cell Lung Cancer
KEYTRUDA, in combination with pemetrexed and platinum chemotherapy, is indicated for the first-line treatment of patients with metastatic nonsquamous non-small cell lung cancer (NSCLC), with no EGFR or ALK genomic tumor aberrations.
KEYTRUDA, in combination with carboplatin and either paclitaxel or paclitaxel protein-bound, is indicated for the first-line treatment of patients with metastatic squamous NSCLC.
KEYTRUDA, as a single agent, is indicated for the first-line treatment of patients with NSCLC expressing PD-L1 [Tumor Proportion Score (TPS) ≥1%] as determined by an FDA-approved test [see DOSAGE AND ADMINISTRATION], with no EGFR or ALK genomic tumor aberrations, and is:
    stage III where patients are not candidates for surgical resection or definitive chemoradiation, or    metastatic.
KEYTRUDA, as a single agent, is indicated for the treatment of patients with metastatic NSCLC whose tumors express PD-L1 (TPS ≥1%) as determined by an FDA-approved test [see DOSAGE AND ADMINISTRATION], with disease progression on or after platinum-containing chemotherapy. Patients with EGFR or ALK genomic tumor aberrations should have disease progression on FDA-approved therapy for these aberrations prior to receiving KEYTRUDA.

What is Venclexta?Venclexta contains the prescription medicine venetoclax, classed as a B-cell lymphoma-2 (BCL-2) inhibitor.Venetoclax can be used alone or in combination with rituximab for the treatment of adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), or in combination with azacitidine, decitabine, or cytarabine for the treatment of adults with newly diagnosed acute myeloid leukemia (AML) who are 75 years of age or older, or have other medical conditions that do not allow the use of other chemotherapy.Your first dose of venetoclax may be given to you in a hospital or clinic setting just in case you have serious side effects that need treating. The tablets should be taken whole with food and water at the same time each day, and not crushed or chewed. You will need to drink 6 to 8 glasses of water daily for 2 days before you start taking Venclexta, on the first day you take them and when your dose is changed, to stop certain side effects. Your blood will be tested on a regular basis as venetoclax can reduce your blood cell count.Venclexta active ingredientsVenetoclax specifically blocks the action of BCL-2, a naturally occurring protein in the body. In conditions such as CLL and AML excess amounts of BCL-2 have been seen to be produced. BCL-2 helps tumor cells to resist being destroyed by chemotherapy.By attaching to BCL-2, venetoclax allows the natural cycle of cell death to resume, by allowing certain enzymes to carry out their normal function of destroying cells. Venetoclax has been shown in studies to be toxic to tumor cells that have high BCL-2 levels.Venclexta side effectsThe most common side effects caused by Venclexta include:    Nausea, Diarrhea    Tiredness    Easily bruised    Unusual bleeding    Sore throat, stuffy nose, sneezingIn rare instances, Venclexta can cause more serious side effects. These can include:    Symptoms of pneumonia – sharp chest pain, difficulty breathing, yellow/green mucus cough    Anemia (low blood cells) – pale or yellow skin, flu-like symptoms, fever, skin and mouth sores, confusion, feeling weak    Symptoms of breakdown of tumor cells – muscle or joint pain, tiredness, shortness of breath, irregular heartbeat, nausea, vomiting, seizures, dark or cloudy urineYour doctor will assess the benefits of using Venclexta against your risk of side effects.Venclexta drug interactionsVenclexta can interact with other medications. These include:    Treatment for an irregular heartbeat – amiodarone, dronedarone    Antiviral medication for the treatment of HIV/AIDS – atazanavir, darunavir, indinavir, ritonavir    Vaccines – bcg, influenza, measles, mumps, polio, rubella, smallpox, typhoid, varicella, yellow fever, zoster live    Treatment for hypertension – captopril    Anticonvulsants for seizures – carbamazepine, phenobarbital, phenytoin    Antibiotics – ciprofloxacin, erythromycin, rifampin    Steroid treatment – dexamethasone    Treatment for autoimmune diseases – etanercept    Antifungal treatments – fluconazole, itraconazole, ketoconazole    Immunosuppressants – fingolimod, ozanimod, siponimod    DMARDs (disease-modifying anti- rheumatic drugs) leflunomide, teriflunomide    Medication for the treatment of angina or high blood pressure – nifedipine, felodipineThis list is not exhaustive and other drugs may interact with Venclexta.Venclexta warning and precautionsYou should not use Venclexta if you:    Are allergic to the active ingredient venetoclax    Are allergic to any of the other ingredients in Venclexta    Are pregnant or are planning to become pregnant    Are breastfeeding or are planning to breastfeed     Talk to your doctor before using Venclexta if you:    Are taking any of the medications that could interact with Venclexta    Have liver disease    Have kidney disease    Have hypokalemia (low potassium levels)    Have hypocalcemia (low calcium levels)    Have gout or high levels of uric acid in your blood    Are taking a blood thinner such as warfarin